Results Published in Study Show MolecuLight Fluorescence Point-of-Care Imaging Detected Pseudomonas Aeruginosa (PA) in Wounds with a PPV of 93% Protection Status
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Toronto, Canada – March 2, 2021 – MolecuLight Inc., provider of a point-of-care fluorescence imaging for point-of-care detection of wounds containing elevated bacterial loads, announced the publication of results from an independent, prospective clinical trial of 28 wounds in Diagnostics titled “Rapid Diagnosis of Pseudomonas aeruginosa in Wounds with Point-of-Care Fluorescence Imaging”.

Pseudomonas aeruginosa (PA) is a common bacterial pathogen in chronic wounds known for its propensity to form biofilms and evade conventional treatment methods. PA infection is a common occurrence in chronic wounds1 and early detection of PA in wounds is critical to mitigate more severe wound outcomes. PA in wounds is associated with rapid wound deterioration,2 higher rates of skin graft failure,3 and higher rates of sepsis. Results from this clinician-directed study show that fluorescence imaging using the MolecuLight i:X® can rapidly detect PA in chronic wounds. In the study, chronic wounds in which cyan was observed had tissue samples taken for culture analysis. Results of this analysis reveal that the cyan fluorescence detected in MolecuLight i:X images was predictive of PA in 93% of study wounds, yet less than 20% of the wounds exhibited the ‘classic’ symptoms of Pseudomonas.

“I see non-healing wounds every day and struggle because the cause is often unclear. The ability to screen patients’ wounds on the spot and differentiate wounds harboring Pseudomonas is a substantial clinical advantage that enables me to adjust therapy immediately”, says Rose Raizman, the study’s author and wound care specialist at Scarborough Health Network, Lawrence S. Bloomberg Faculty of Nursing at the University of Toronto. “The study’s findings and my clinical experience with the MolecuLight i:X suggest that cyan detected on fluorescence images can be used to reliably predict Pseudomonas at the point-of-care”.

The need for definitive methods to improve bacterial detection in wounds at point-of-care is indisputable, given that >80% of wounds with high bacterial loads are missed by routine assessment.6,7 The pathogenicity of PA and its propensity for biofilm formation8-11 make its rapid detection critical. Clinical guidelines advise use of clinical signs and symptoms to aid in the early detection of PA;5 however, these symptoms frequently fail to mount in infected wounds. Indeed, in this study, less than 20% of wounds that were positive for PA exhibited these symptoms. As such, clinicians may be missing the majority of wounds containing PA. This study illustrates how point-of-care fluorescence imaging, alongside assessment of clinical signs and symptoms of infection, may help to overcome these challenges. Fluorescence imaging potentially enhances detection of PA in wounds and also provides real-time information to wound care clinicians related to the efficacy of treatments targeted to eradicate PA.

1. de Oliveira, F.P et al, J. Wound Ostomy Cont. Nurs. 2017, 44, 528–535.
2. Turner KH et al, PLoS Genet 2014
3. Hogsberg T et al, PLoS One 2011
4. McManus AT et al, Eur J Clin Microbiol 1985
5. Mutluoglu, M. et al, Can. Med. Assoc. J. 2011, 183, E499. 6Le, L. et al,. Adv. Wound Care 2020.
7. Reddy, M, JAMA 2012, 307, 605–611. 8Schaber, J.A. et al, Infect. Immun. 2007, 75, 3715–3721.
9. Kamali, E et al., BMC Res. Notes 2020, 13, 27.
10. Drenkard, E. et al, Nature 2002, 416, 740–743,
11. Aloush, V. et al, Antimicrob. Agents Chemother. 2006, 50, 43–48.

About MolecuLight
MolecuLight is the manufacturer of MolecuLight i:X®, a real-time handheld fluorescence imaging device.

The views and opinions expressed in this blog are solely those of the author, and do not represent the views of WoundSource, Kestrel Health Information, Inc., its affiliates, or subsidiary companies.

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