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Anti-Biofilm Synergy of Innovative Wound Cleanser and Gel Components

Other presenters

Rebecca E. McMahon, PhD1
Joseph C. Salamone, PhD1
Suprena Poleon2
Nina Bionda3
Peter D’Arpa, PhD4
1. Rochal Industries, San Antonio, TX
2. University of North Texas Health Science Center, Fort Worth, TX
3. iFyber LLC, Ithaca, NY,
4. BiomedWrite, North Potomac, MD

Poster location

Biofilms are complex composites which evolve continuously as stimulated by the wound environment as well as the environment within the biofilm. The chemical composition of microbial cells and their EPS, and the overall architecture of a biofilm, changes with pH, osmolality, oxygen concentration, water concentration, temperature, nutrient availability, cellular excrement concentration and microbial diversity, for example. An integrated approach using theoretical chemistry and biochemistry mechanisms for biofilm disruption and microbial kill resulted in the development of a set of synergistic components incorporated in a unique Antimicrobial Skin and Wound Cleanser (AWC)* and Antimicrobial Wound Gel (AWG)+.

Synergy of the components was determined by Kull equation analysis based on MBEC peg biofilm assay results utilizing mono-species P. aeruginosa and S. aureus (MRSA) biofilms. T-tests with unequal variances were performed on the ranked data using the R function pairwise. t.test non.

The Kull equation analysis for synergism provided a Synergy Index (SI) of 0.148 with P. aeruginosa and 0.032 with MRSA. Ex vivo porcine explant testing and human clinical results support the synergy analysis. Conclusion: As an SI = 1 indicates an additive functionality and an SI > 1 indicates antagonistic functionality, these SI values

*Sanara MedTech, Inc. BIAKŌS™Antimicrobial Skin and Wound Cleanser +Sanara MedTech, Inc. BIAKŌS™Antimicrobial Wound Gel