Applications of Bioactive Glass in Tissue Repair and Wound Healing

Lead Presenter

Supporting Presenters

William Li, M.D.
Steven Jung, Ph.D.
Delbert Day, Ph.D.
Chad Lewis, Ph.D.
David G. Armstrong, D.P.M., M.D., Ph.D.

Presented At

Abstract

Bioactive glass (BG) is a human-made material that has recently emerged as a new technology for treating acute and chronic wounds with significant potential for podiatric surgical applications.1 Flexible bioactive glass microfiber that mimics the microenvironment of a fibrin clot have been used in direct contact with open wounds to help facilitate the body’s typical cellular healing response.2-3 Bioactive glass is resorbable in the wound bed and dissolves at a physiologic rate similar to a fibrin clot. As the BG dissolves, it releases ions of calcium, sodium, potassium, magnesium, and phosphorus at concentrations similar to those found in human blood plasma.4 This presentation will review the literature regarding the potentially beneficial characteristics of BG including anti-infective,5 angiogenic,6 and anti-inflammatory effects7 in pre-clinical models. FDA cleared products based on BG technology are now actively being used clinically for wounds below the knee and demonstrating great promise in recalcitrant diabetic wounds in a post-market randomized controlled clinical study.

References
1. Rahaman MN, Day DE, Sonny Bal B, et al. Bioactive glass in tissue engineering. Acta Biomater. 2011;7(6):2355-2373. doi:10.1016/j.actbio.2011.03.016.
2. Jung SB. Wound healing power of glass. Nanotech Insights. 2011;2(3):2-4. RNI No. APENG/2-10/34023. ISSN 2229-5992.
3. Jung SB. Treatment of chronic wounds with bioactive borate glass fibers. An Introduction to Bioceramics, 2nd Edition. 2013;(33):1-7 ISBN-13: 978-1908977151
4. Jung, SB., "Borate based bioactive glass scaffolds for hard and soft tissue engineering" (2010).Doctoral Dissertations. 2075. http://scholarsmine.mst.edu/doctoral_dissertations/20755.
5. Ottomeyer M, Mohammadkah A, Day D, Westenberg D. Broad-Spectrum Antibacterial Characteristics of Four Novel Borate-Based Bioactive Glasses. Adv Microbiol. 2016;6(10):776-787. doi:10.4236/aim.2016.610076.
6. Lin Y, Brown RF, Jung SB, Day DE. Angiogenic effects of borate glass microfibers in a rodent model. J Biomed Mater Res Part A. 2014;102(12):4491-4499. doi:10.1002/jbm.a.35120.
7. Dong X, Chang J, Li H. Bioglass promotes wound healing through modulating the paracrine effects between macrophages and repairing cells. J Mater Chem B. 2017 ,5, 5240-5250. doi 10.1039/C7TB01211J.