Complex Venous Leg Ulcer with Underlying DVT and Factor V Leiden Healed Using Novel Omega Fatty Acids Based Therapy

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Complex Venous Leg Ulcer with Underlying DVT and Factor V Leiden Healed Using Novel Omega Fatty Acids Based Therapy
Jacob Reinkraut, DPM, FACFAS 1, Adeen Khokhar, DPM, PGY-31, Sarah Abdou, DPM PGY-21, Sonya Wali, DPM PGY-11, Desmond Bell, DPM, CWS, FF RCPS (Glasgow)2
1 St. Michael’s Medical Center, Newark, NJ
2 The Save a Leg, Save a Life Foundation

Venous leg ulcerations (VLU’s) account for a minimum of 70% of chronic wounds (1). Delayed healing is associated with VLU’s greater than 10cm2 and three months or greater in duration (1, 2). Annual cost of care in the US is estimated to be $16 billion (1). The ability to accelerate healing while reducing costs can help curtail some of this expense. Presented here is a case report of a chronic VLU that resolved in under three months with use of an omega-based complete care protocol used once weekly in an outpatient setting.

Case Report
A 54-year-old African American male with a VLU of 5 months duration presented with failure to heal and 10/10 pain requiring oral analgesic use. The patient had previously undergone surgical debridement and xenograft application. Weekly treatment with an anhydrous omega-based bundle product package focused on wound and periwound preparation prompted healing to begin. Pain rapidly resolved and wound resolution occurred at 11 weeks.

High-quality studies on advanced tissue product use in the treatment of VLU’s report healing rates between 44 to 84% at 12-weeks (average baseline size ~6cm2) (1-6). None of these modalities address the periwound skin which is often in poor condition after months of weekly compression dressing use. Preclinical trials of therapies utilizing omega-3 polyunsaturated fatty acids show reduced inflammatory cell recruitment, enhanced perfusion, decreased bacterial growth and disruption of biofilm (7 - 16). Their use also provides protection and improved texture to the periwound skin. This may help propel chronic wounds towards resolution and potentially mitigate wound recurrence.

Use of an omega-based complete care protocol resulted in expedited resolution of a chronic venous leg ulceration in a patient that had failed prior advanced treatment modalities.


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