Epithelialization of porcine partial thickness wounds following application of collagen dressings

Topics: 

Abstract

Background: The current study assessed differences in epithelialization following the application of three different collagen dressings to porcine partial thickness wounds.

Methods: Paraspinal partial-thickness wounds were created using a dermatome (5 cm x 5 cm, 500 m deep) in Yorkshire swine (n = 3). Three different collagen based dressings with porcine collagen (collagen 1#), ovine collagen (collagen 2*) or oxidized regenerated cellulose and collagen (collagen 3+) were used to treat these wounds. Wounds were then covered with a secondary foam dressing to manage exudate. After 72 hours, tissue samples were collected, and re-epithelial coverage was estimated from H&E stained sections.

Results: Neoepithelial coverage was 40% for Collagen 1, 38% for Collagen 2, and 59% for Collagen 3. Epithelial coverage for collagen 3 was significantly improved at this time point (p

Conclusion: Collagen 3 demonstrated improved re-epithelialization in a skin graft donor site pre-clinical model, suggesting that it can improve closure rates for this wound type and potentially in other wounds requiring epithelialization. The data presented are consistent with Chowdhry1 who showed in a retrospective study that graft donor sites were re-epithelialized more quickly when collagen 3 dressings were used.

*Endoform® Natural Dermal Template (Aroa Biosurgery Ltd, New Zealand)
#BIOSTEP Collagen Matrix Dressing (Smith and Nephew, Hull, UK)
+Promogran™ Matrix Wound Dressing (3M, Maplewood, MN)

  1. Chowdhry, S.A. 2019. JPRAS, 22: 33-40.

graph_1_1.png

Important Notice: The contents of the website such as text, graphics, images, and other materials contained on the website ("Content") are for informational purposes only. The Content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. The content is not intended to substitute manufacturer instructions. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition or product usage. Refer to the Legal Notice for express terms of use.