Biobrane® is a biocomposite dressing of nylon fibers embedded in silicone to which collagen has been chemically bound.
• Minimizes proliferation of bacteria on the wound surface by minimizing dead space
• Blood/sera clot in the matrix, adhering the dressing to wound
• Water vapor loss rates controlled at rate comparable to skin
• Uses flexible adherent covering for wound surface
• Allows joint movement and early ambulation
• Conforms to surface irregularities
• Highly flexible and conformable
In rare instances, allergic reactions to BIOBRANE/BIOBRANE-L have been reported. If a patient shows evidence of an allergic reaction, BIOBRANE/BIOBRANE-L should be removed and its use discontinued.
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Partial-Thickness Burn Wounds
Application should be to freshly debrided or excised wounds, or meshed autografts containing less than 105 bacteria/g tissue.
The debridement or excision must be done thoroughly to remove all coagulum or eschar. BIOBRANE/BIOBRANE-L will not adhere to dead tissue and any remaining necrotic tissue may cause infection.
Establish hemostatis prior to application of BIOBRANE/BIOBRANE-L.
Apply fabric (dull) side down, wrinkle-free against the wound surface with slight tension.
If less secondary adherence is desired (e.g. deeper donor sites or meshed autografts), BIOBRANE-L is recommended.
Under slight tension immobilize BIOBRANE/BIOBRALE-L using staples, tape, sutures, or skin closure strips and wrap area with a dry gauze dressing or other stenting device to hold the dressing firmly in contact with the wound surface for 24 to 36 hours.
24 Hours Postapplication: Do not remove the outer dressing. Do not get the dressing wet. Do not move the covered area more than necessary.
24 to 36 hours Postapplication: Remove the outer dressing down to the BIOBRANE/BIOBRANE-L and observe for the following: If the BIOBRANE/BIOBRANE-L is adherent and no fluid accumulation is present, rewrap with gauze for protection. If the BIOBRANE/BIOBRANE-L is loose, but the underlying tissue is still viable, aspirate or roll out any nonpulurent fluid collection, rewrap with a gauze dressing and observe in 24 hours for adherence. If the BIOBRANE/BIOBRANE-L is loose and there is purulent drainage underneath, remove the purulent nonadherent areas and use conventional topical antimicrobial therapy to reduce bacterial contamination to safe levels.
48 to 72 hours Postapplication: Remove the outer dressing down to BIOBRANE/BIOBRANE-L and check for adherence. If adherent, the outer dressing need not be reapplied. If nonadherent, treat as referenced above. Observe the covered wound daily for bubbles and purulence and treat as referenced above. BIOBRANE/BIOBRANE-L should be removed from areas of the wound with signs of infection. Remove staples, tape, sutures, or skin closure strips three to four days postapplication or when adherence is achieved. Once the BIOBRANE/BIOBRANE-L is adherent, patients can be bathed according to standard burn unit protocols, and motion of the burned area can be initiated.
Remove the BIOBRANE/BIOBRANE-L when the tissue underneath is healed, typically 7 to 14 days. The dressing should be dry and loose in spots, and the patient may report itching.
If edges are loose, they can be trimmed away until the entire wound is healed.
Remove by starting at one corner and pull gently. BIOBRANE/BIOBRANE-L will peel off healed tissue relatively easily. The application of a petroleum based ointment or soaking prior to removal facilities the removal process.
Caution: If bleeding occurs, or if the patient complains of excessive pain, stop and wait 1 to 2 additional days. Forced removal may result in wound reinjury. Also, if BIOBRANE/BIOBRANE-L becomes adherent to a partial-thickness wound which has progressed to a full-thickness wound, it should be removed in the operating room.
Under slight tension immobilize BIOBRANE/BIOBRANE-L using staples, tape, sutures, or skin closure strips and wrap area with a dry gauze dressing or other stenting device to hold the dressing firmly in contact with the wound surface for 24 to 36 hours.
Mylan is a distributor of burn and wound care products and medical devices, emphasizing quality of products, customer service and improvement of patient care.