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Integra® Flowable Wound Matrix

Integra® Flowable Wound Matrix is an advanced wound care device comprised of a granulated Integra® Wound Matrix, which consists of collagen and glycosaminoglycan. The Integra® Flowable Wound Matrix is hydrated with saline prior to application. It is designed for use in deep soft tissue or tunneling wounds.

Integra LifeSciences Corp.

Integra LifeSciences, a world leader in medical technology, is dedicated to limiting uncertainty for surgeons so they can concentrate on providing the best patient care. Integra offers innovative solutions in orthopedic extremity surgery, neurosurgery and reconstructive and general surgery.
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• Gel-like consistency allows intimate contact between the grafting material and wound bed
• Composition and method of administration allows for complete coverage in deep crevice wounds
• Provides a resorbable scaffold on which cells can attach, migrate, proliferate and differentiate


Integra® Flowable Wound Matrix is indicated for the management of wounds including: partial- and full-thickness wounds, pressure ulcers, venous ulcers, diabetic ulcers, chronic vascular ulcers, tunneled/undermined wounds, surgical wounds (donor sites/grafts, post-Mohs surgery, post-laser surgery, podiatric, wound dehiscence), trauma wounds (abrasions, lacerations, second-degree burns, skin tears) and draining wounds. The device is intended for one-time use.


This device should not be used in patients with known sensitivity to bovine collagen or chondroitin materials. This device is not indicated for use in third-degree burns.

Warnings and Precautions

Do not resterilize. Discard all opened and unused portions of the device. Do not use if package seal is broken.

Adverse Effects/Reactions

Complications are possible with the use of wound dressings including infection, chronic inflammation, allergic reaction, excessive redness, pain or swelling.

Storage Requirements

Room temperature with a 18-month shelf life.

How Supplied/Sizing
3cc syringe.
Product features
check_circle Assigned HCPCS code
cancel Minimally manipulated
check_circle Dehydrated
cancel Desiccated
check_circle Flowable
cancel Micronized
cancel Sheet form
cancel Requires refrigeration
cancel Shelf life greater than 2 years
check_circle Shelf life limited
check_circle Indicated for acute wounds
check_circle Indicated for chronic wounds
check_circle Indicated for diabetic ulcers
check_circle Indicated for pressure ulcers
cancel Indicated for second-degree burns
check_circle Indicated for surgical wounds
cancel Indicated for third-degree burns
check_circle Indicated for venous ulcers
cancel Contact manufacturer for usage guidelines
Other features
check_circle Educational Material Available
cancel Free Samples/Trials Available
cancel Published Clinical Article Available
Recommended Use

Acute Wounds
Chronic Wounds
Deep Wounds
Diabetic Foot
Hypertrophic Scars/Keloids
Pressure Ulcers
Surgical Wounds
Venous Ulcers

Mode of Use/Application

Inspect all packaging integrity including protective wrapping, syringes and tip caps. Do not use if packaging is damaged, or tip cap is missing or not fully attached to syringe. Visually inspect the empty syringe. Do not use if empty syringe contains cracks or visible particulate matter. Prepare wound bed using standard methods to ensure wound is free of debris and necrotic tissue. If necessary, surgically debride the wound to ensure the wound edges contain viable tissue.

Peel open all three pouches (dry granulated collagen syringe pouch, empty sterile syringe pouch and the luer lock connector accessory pouch). Pour saline into sterile container and draw 3ml of saline into the empty syringe. Remove tip cap from the 6ml dry collagen syringe and attach luer lock connector to the collagen syringe. Attach the syringe containing saline to the other end of the luer lock connector. Hold both syringes in your hands securely. Dispense all saline fluid into the dry collagen syringe. Depress plungers back and forth at least 15 times to prepare the Integra® Flowable Wound Matrix.

Consider the flowable wound matrix mixed when product appearance is consistent and homogeneous and all the product can be moved from one syringe to the other. Ensure all the mixed material is moved into the 6ml collagen syringe (white plunger). Remove the luer lock connector and the empty syringe while holding the 6ml syringe. Attach flexible injector tip securely to the 6ml syringe. Slowly depress plunger to 3ml to remove air pockets.

When dispensing Integra® Flowable Wound Matrix, first determine the location of the base of the wound bed utilizing the flexible injector. Upon dispensing product into the wound, avoid pressing the injector tip directly against the base of the wound to ensure the product is not prevented from exiting the flexible injector.

After application, use an optimal secondary dressing to maintain matrix adherence and protect the wound area. The optimum dressing is determined by wound location, size, depth and user preference. On inspection, if the wound is not completely filled, use an additional dose of the Integra® Flowable Wound Matrix to complete the procedure.

Removal & Change Frequency

Change the dressing as needed. Frequency of dressing changes will be dependent upon volume of exudate produced, type of dressing used and the clinician's need to inspect the wound bed for signs of infection or healing.

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