Clinical Trials

Thomas Serena's picture
standardizing clinical trial endpoint

By Thomas E. Serena MD, FACS, FACHM, FAPWCA

Recently, I had the pleasure of attending Puccini's opera Turandot at New York's Metropolitan Opera House. In my favorite scene, young prince Calef comes upon a gruesome tableau: Potential suiters for the princess Turnadot must answer three questions correctly in order to win her hand. On the downside, one incorrect answer is rewarded with a beheading. Calef takes the challenge and answers all three questions flawlessly. Yet, the princess begs her father not to force her to marry the stranger. Calef intercedes saying that if she can guess his name before dawn he will release her from her obligation. Confident of conquest, he sings Nessun dorma (none shall sleep), the opera's most famous aria.

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Michel Hermans's picture
Year in review

By Michel H.E. Hermans, MD

At the beginning of a new year, many look back at the previous one in an attempt to analyze what happened, whether it was good or bad or perhaps even special.

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Temple University School of Podiatric Medicine's picture
Wound Care Literature Review

By Temple University School of Podiatric Medicine Journal Review Club

Editor's note: This post is part of the Temple University School of Podiatric Medicine (TUSPM) journal review club blog series. In each blog post, a TUSPM student will review a journal article relevant to wound management and related topics and provide their evaluation of the clinical research therein.

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Ron Sherman's picture
Clinical Research

By Ron Sherman MD, MSC, DTM&H

In my previous post on maggot therapy, we discussed the differences between confinement and containment maggot therapy dressings. This post will examine the studies that address differences in efficacy and efficiency between these two methods of maggot therapy. The majority of contained maggot studies use a specific brand of containment bag (Biobag™ or VitaPad™ by Biomonde) because those products – if not the very act of applying maggots to the wound within a bag – were patented 14 years ago by Wim Fleischmann.1 While numerous individual therapists have applied maggots to wounds by first placing them into bags of their own making, or into commercially available net bags, no company can legally sell contained maggot dressings in any country where the patent was filed. Therefore, the majority of formal studies have used the Biomonde products

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Temple University School of Podiatric Medicine's picture
Wound Care Literature Review

By Temple University School of Podiatric Medicine Journal Review Club

Editor's note: This post is part of the Temple University School of Podiatric Medicine (TUSPM) journal review club blog series. In each blog post, a TUSPM student will review a journal article relevant to wound management and related topics and provide their evaluation of the clinical research therein.

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Temple University School of Podiatric Medicine's picture
Wound Care Literature Review

By Temple University School of Podiatric Medicine Journal Review Club

Editor's note: This post is part of the Temple University School of Podiatric Medicine (TUSPM) journal review club blog series. In each blog post, a TUSPM student will review a journal article relevant to wound management and related topics and provide their evaluation of the clinical research therein.

Temple University School of Podiatric Medicine's picture
Journal Club Review

By Temple University School of Podiatric Medicine Journal Review Club

Editor's note: This post is part of the Temple University School of Podiatric Medicine (TUSPM) journal review club blog series. In each blog post, a TUSPM student will review a journal article relevant to wound management and related topics and provide their evaluation of the clinical research therein.

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Temple University School of Podiatric Medicine's picture
Vashe Wound Solution

By Keval Parikh and James McGuire DPM, PT, CPed, FAPWHc

An important aspect of the field of wound care is the proper preparation of the wound bed. Key points in wound bed preparation include minimizing exudate, assistance in the facilitation of the body’s healing process, and helping to produce a well-vascularized, stable wound that is free of microbes.

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Thomas Serena's picture
Hyperbaric Chamber

by Thomas E. Serena MD, FACS, FACHM, FAPWCA

Pete Seeger died a year ago last January at the age of 94. Reading a tribute to the folk singer, I ran across his most memorable tune, "Where have all the flowers gone?" I have long enjoyed the numerous versions of this folk song recorded by dozens of artists. The fatalism of the lyrics and the circular verse form made it emblematic of a most unfortunate decade in American life: the 60s.

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Michel Hermans's picture
Keywords: 

By Michel H.E. Hermans, MD

Merriam Webster defines bias as "selecting or encouraging one outcome or answer over others." The Cochrane handbook states: "The reliability of the results of a randomized trial depends on the extent to which potential sources of bias have been avoided."

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