Cellular- and/or tissue-based products (CTPs) are types of wound dressings or coverings that support wound healing. There are multiple options for these products, including: non-viable cells, tissue-based: animal; non-viable cells, tissue-based: human; viable human cells, cultured in vitro: animal substrate; viable human cells, cultured in vitro: synthetic substrate; and viable human cells, non-cultured: intact tissue.
In January 2026, new Final Rules regarding CTP/skin substitute application are scheduled to go into effect. Please consult your region’s Local Coverage Determination and/or your local payers’ guidelines for specific details on coverage and use specifications. Products listed in WoundSource may or may not be on the covered list under the new guidelines, so it is imperative that readers verify coverage policies, medical necessity requirements, and coding instructions for their desired product(s). See pages [XXX] for full disclaimer information.
NuShield® is a sterile and shelf-stable dehydrated placental allograft wound covering that retains all the layers of the placental membrane due to the novel LayerLoc™ preservation method.
OASIS® Burn Matrix is a natural extracellular matrix (ECM) derived from 2 layers of porcine small intestinal submucosa. Provides an intact three-dimensional extracellular matrix which allows for host cell migration. Its thickness allows for easy fixation and retention of sutures and staples if necessary.
OASIS® MICRO Micronized Wound Matrix is an advanced wound care product comprised of micronized extracellular matrix (ECM) from porcine small intestinal submucosa used to manage wounds. It is a three-dimensional extracellular matrix that retains the natural composition of matrix molecules, provides a scaffold for cellular invasion and capillary growth and maintains and supports a healing environment for wound management.
OASIS® ULTRA Tri-Layer Matrix is a natural extracellular matrix (ECM) derived from 3 layers of porcine small intestinal submucosa (SIS) technology. The technology provides an intact three-dimensional extracellular matrix which allows for host cell migration. The three-layer construct is designed with surgeons in mind for increased strength, thickness, and durability. These attributes provide handling/flexibility and more fixation options.
OASIS® Wound Matrix is a natural extracellular matrix derived from a single layer of porcine small intestinal submucosa (SIS) technology. The technology provides an intact three-dimensional extracellular matrix which allows for host cell migration. Storage at room temperature with a shelf-life of two years.
Restrata® is a fully synthetic hybrid-scale fiber matrix manufactured with synthetic bioresorbable polymers and possesses a fibrous structure with high porosity. The product architecture, which is similar to native extracellular matrix, allows for cell ingress and retention, as well as neovascularization of the newly forming tissue without the need for added growth factors.
