Cellular- and/or Tissue-Based Products

Cellular- and/or tissue-based products (CTPs) are types of wound dressings or coverings that support wound healing. There are multiple options for these products, including: non-viable cells, tissue-based: animal; non-viable cells, tissue-based: human; viable human cells, cultured in vitro: animal substrate; viable human cells, cultured in vitro: synthetic substrate; and viable human cells, non-cultured: intact tissue. 

In January 2026, new Final Rules regarding CTP/skin substitute application are scheduled to go into effect. Please consult your region’s Local Coverage Determination and/or your local payers’ guidelines for specific details on coverage and use specifications. Products listed in WoundSource may or may not be on the covered list under the new guidelines, so it is imperative that readers verify coverage policies, medical necessity requirements, and coding instructions for their desired product(s). See pages [XXX] for full disclaimer information.