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Cryo-Cord™ is a cryopreserved placental umbilical cord allograft that may be used as an anatomical barrier in numerous clinical applications. Retains the natural properties of placental tissue including nutrient-rich growth factors, cytokines, endogenous cells and Wharton's Jelly.

Royal Biologics, Inc.

Royal Biologics manufactures minimally-invasive autologous live cellular therapy products through orthobiologic device innovations that use bioactive cells to help promote healing in a range of clinical settings.
Fax:(270) 721-6932 Website:

• Placental tissue acts as an immune-privileged protective barrier during fetal development
• Acts as an anatomical barrier that helps provide mechanical protection while retaining endogenous growth factors
• Proprietary process preserves the natural properties of placental umbilical cord tissue, maintaining inherent levels of key extracellular matrix molecules, including proteins, carbohydrates, growth factors and cytokines
• Contains viable endogenous cells cryopreserved in a proprietary DMSO-free cryoprotectant


Cryo-Cord™ is intended for use as a soft tissue barrier or wound covering.


Cryo-Cord™ has no known contraindications.

Warnings and Precautions

The donors of Cryo-Cord™ are screened and tested for relevant communicable diseases and disease agents in compliance with the FDA regulations, relating to human cells, tissues and cellular and tissue-based products (21 CFR part 1271). Cryo-Cord™ is processed using aseptic techniques and microbiologically tested. Although all efforts have been made to ensure the safety of the allograft, there is no assurance that this allograft is free from all infectious diseases or microbial contamination.

Adverse Effects/Reactions

Allogeneic cells or tissues can induce an immunologic response in the recipient. The possibility that a patient may develop alloantibodies should be considered for any patient who might be a future recipient of allograft tissue or cells.
Possible adverse events may include: immunologic response, transmission of disease of unknown etiology and transmission of infectious agents including but not limited to: HIV, hepatitis, syphilis or microbial contaminants.

Storage Requirements

Cryo-Cord™ must be stored at -65˚C or colder. It is the responsibility of the tissue dispensing service, tissue distribution intermediary and/or end-user clinician to maintain the allograft in appropriate storage conditions prior to further distribution or use and to track expiration dates accordingly. Appropriate inventory control should be maintained so that the allograft with the earlier expiration date is preferentially used and expiration is avoided.

How Supplied/Sizing
2cmx2cm, 2cmx4cm, 3cmx6cm.
Product features
cancel Assigned HCPCS code
cancel Minimally manipulated
check_circle Cryopreserved
check_circle Requires refrigeration
cancel Sheet form
cancel Shelf life greater than 2 years
check_circle Shelf life limited
check_circle Indicated for acute wounds
check_circle Indicated for chronic wounds
check_circle Indicated for diabetic ulcers
check_circle Indicated for pressure ulcers
check_circle Indicated for surgical wounds
cancel Indicated for third-degree burns
check_circle Indicated for venous ulcers
cancel Contact manufacturer for usage guidelines
Other features
check_circle Educational Material Available
check_circle Free Samples/Trials Available
check_circle Published Clinical Article Available
Recommended Use

Acute Wounds
Chronic Wounds
Deep Wounds
Dehisced Wounds
Diabetic Foot
Granulating/Epithelializing Wounds
Infected Wounds
Moderate/Highly Exudating Wounds
Non/Minimally Exudating Wounds
Palliative Wounds
Pressure Ulcers
Sloughy Wounds
Superficial Wounds
Surgical Wounds
Venous Ulcers

Clinically Tested


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