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PoDiaPN® is a medical food designed to address nutritional requirements associated with diabetic peripheral neuropathy and its vascular complications. Clinically-effective nutrient levels address oxidant and inflammation pathways, hyperhomocysteinemia, and endothelial dysfunction.


Pharmaceutix® offers PoDiaPN®, a medical food for adjunctive use under physician supervision for patients with distinctive nutritional requirements related to diabetic peripheral neuropathy and its vascular complications.
Toll free:(800) 647-6100 Fax:(407) 445-0204 Website:

• Provides nutrients to address needs related to diabetic peripheral neuropathy and its vascular complications
• Addresses oxidant and inflammation pathways
• Assists in the reduction of excess homocysteine
• Addresses endothelial dysfunction-increases production of nitric oxide which enhances blood flow for delivery of oxygen and nutri
• Formulated without major allergens, GMOs, artificial colors, preservatives, or gluten
• Easy-to-swallow capsule


For patients with distinctive nutritional requireents to peripheral nerves and tissue
• (6S)-5MTHF, glucosamine salt bypasses MTHFR polymorphisms
• (6S)-5 MTHF, glucosamine salt compared to calcium salt form -10% greater bioavailability*
• (6S)-5 MTHF, glucosamine salt compared to calcium salt form -100% more water soluble*ments associated with diabetic peripheral neuropathy and its vascular complications.


PoDiaPN® is contraindicated in anyone with a known hypersensitivity to any of the components. Alpha
lipoic acid is contraindicated in individuals who are thiamine deficient.

Warnings and Precautions

Children, pregnant or nursing women, women of childbearing age who may become pregnant should consult with their practitioner before use. Patients taking agents that lower blood pressure, affect blood sugar levels, or increase bleeding risk should be monitored. High-dose folic acid intake without concurrent vitamin B12 supplementation may mask the symptoms of pernicious, aplastic, or normocytic anemias caused by vitamin B12 deficiency. (6S)-5-MTHF is less likely than folic acid to mask B12 deficiency.

Adverse Effects/Reactions

Patients taking a combination of B vitamins at levels that are comparable to those found in PoDiaPN® have reported numbness in two fingers, dizziness, and balance disorder. Folic acid supplementation has been reported to cause gastrointestinal (GI) distress, irritability, excitability, sleep disturbances, and allergic reactions in some individuals. Human trials using 0.4 to 17 mg/day of (6S)-5-MTHF showed an absence of adverse effects. Paresthesia, somnolence, nausea and headaches have been reported with pyridoxal 5’-phosphate [coenzyme form of Vitamin B6]. Doses of B6 under 200 mg/d are not likely to cause adverse effects unless an individual is particularly sensitive. Neurological and GI disturbances and skin reactions have been reported. Excessive doses may cause reversible sensory neuropathy. Vitamin B12 may cause GI disturbances, polycythemia vera, or allergic reactions in sensitive individuals. ALA may cause mild skin rash, GI complaints, or dizziness; these are primarily associated with doses over 1200 mg/d. This is not a comprehensive list of adverse reactions, others may occur. Consult a current, comprehensive database for all potential adverse reactions

Storage Requirements

Store at 20° to 25° C (68° to 77° F)
Excursions between 15° and 30° C (59° and 86° F)

Active Ingredients

Vitamin B6 as Pyridoxal 5’-phosphate
Folate as (6S)-5-methyltetrahydrofolic acid, glucosamine salt
VItamin B12 as Methylcobalamin

Inactive Ingredients

Alpha-lipoic acid, capsule (HPMC, titanium dioxide, sodium copper chlorophyllin), vegetable stearic acid, vegetable magnesium stearate, silica, microcrystalline cellulose.

How Supplied/Sizing
Bottle of 60 capsules
Product features
cancel Amino acid - Arginine
check_circle At-risk formulation
cancel Fiber added
cancel High protein
cancel Liquid
cancel Minimum 25% RDI vitamins/minerals
cancel Oral-feeding
cancel Plant-based formula
cancel Powder
cancel Pudding
cancel Tube-feeding
cancel Wound patient formula
Other features
check_circle Educational Material Available
check_circle Free Samples/Trials Available
cancel Published Clinical Article Available
Recommended Use

Diabetic Foot

Mode of Use/Application

Take one capsule twice daily with or without food, or as directed by your physician.

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