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AC5® Advanced Wound System

AC5® Advanced Wound System is a synthetic peptide-based advanced wound dressing. Applied as a viscous peptide solution and self-assembles into a barrier scaffold when contacting the wound.

Arch Therapeutics

Arch Therapeutics is developing a novel approach to stop bleeding (hemostasis), control leaking (sealant) and manage wounds during surgery, trauma and interventional care using a self-assembling peptide platform.

• Biodegradable and biocompatible to reduce risk of adverse effects
• Conforms to diverse wound beds to enable optimal coverage
• Provides moist healing environment
• Provides protective barrier to mitigate contamination and modulate inflammation
• Provides extracellular scaffold to enable cell growth and healing
• Naturally absorbed to reduce risk of pain or tissue damage with dressing changes
• Aids epithelialization and granulation tissue formation
• Supports opportunities for more aggressive debridement in non-surgical or lower acuity clinic settings
• Clinically demonstrated to benefit healing times in complex and chronic wounds


Under supervision of a health care professional, AC5® Advanced Wound System (AC5) is a topical dressing used for the management of partial- and full-thickness wounds, such as pressure injuries, leg ulcers, diabetic ulcers, and surgical wounds.

Warnings and Precautions

For Topical External Use Only. Do not inject AC5 into blood vessels.
AC5 is not intended to be used as a hemostatic agent.
Use AC5 only with the components provided in the product kit.
Prior to use, prepare the AC5 solution by reconstituting the lyophilized peptide with Sterile Water for Injection, USP. Do not use the lyophilized peptide in powder form on wounds.
The reconstituted peptide solution is acidic (pH 2.3 ± 0.7).
Excess AC5 may be removed by sterile gauze.

For single use only. Do not resterilize.
The safety and effectiveness of AC5 with or as a carrier for antibiotic solutions has not been tested.
The interaction of AC5 with antiseptics such as alcohol or povidone has not been investigated. If any antiseptic has been used near or on the wound, AC5 should not be applied until after the application site is cleaned to remove any such substances.
The control of blood glucose as well as appropriate pressure relief measures should be provided with diabetic foot ulcers.
Where infection is suspected or develops during the use of AC5, the progress of the wound should be monitored carefully. Consult a healthcare professional if the condition worsens or any of the following are noted: fever, increased pain, redness, bleeding, swelling, unusual odor, increased drainage or cloudy or foul drainage.

Storage Requirements

AC5 should be stored between 59°F and 77°F.
Do not freeze.

Inactive Ingredients

Synthetic peptide

Product features
check_circle Biosynthetic
cancel Biosynthetic - animal-based
check_circle Indicated for chronic vascular ulcers
check_circle Indicated for diabetic ulcers
cancel Indicated for draining wounds
check_circle Indicated for partial- and full-thickness wounds
check_circle Indicated for pressure ulcers
check_circle Indicated for surgical wounds
cancel Indicated for third-degree burns
check_circle Indicated for trauma wounds
check_circle Indicated for venous ulcers
cancel Synthetic
cancel Variety of sizes
cancel Resorbable
cancel Contact manufacturer for usage guidelines
Other features
check_circle Educational Material Available
check_circle Free Samples/Trials Available
check_circle Published Clinical Article Available
Recommended Use

Acute Wounds
Chronic Wounds
Dehisced Wounds
Diabetic Foot
Dry Skin Conditions
Granulating/Epithelializing Wounds
Hypertrophic Scars/Keloids
Non/Minimally Exudating Wounds
Palliative Wounds
Pressure Ulcers
Sloughy Wounds
Superficial Wounds
Surgical Wounds
Traumatic Wounds
Venous Ulcers

Mode of Use/Application

Supplied as a lyophilized powder in complete kit for reconstitution and application:
1. Inspect package contents, remove vial caps and swab vial tops with alcohol wipe.
2. Transfer 1.5 ml of diluent with provided needle and syringe to peptide vial, and shake vigorously to dissolve powder.
3. Draw solution into syringe and replace needle with blunt applicator.
4. Apply AC5 solution to wound and cover both with occlusive dressing.

Removal & Change Frequency

AC5 is bioresorbable and does not require removal
Re-apply weekly or as necessary


Synthetic self-assembling peptide solution.

Clinically Tested


Technical Specifications

Synthetic self-assembling peptide solution.

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