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Collagenase SANTYL* Ointment

Collagenase SANTYL* Ointment debrides necrotic tissue.

Smith+Nephew, Inc.

For over 150 years, Smith+Nephew has taken a pioneering approach to product design and services, helping to reduce the human and economic costs of wounds. *Trademark of Smith+Nephew
Toll free:(800) 876-1261 Fax:(817) 900-4100 Website:

• Continuous removal of necrotic materials helps prevent accumulation of harmful debris
• Actively and selectively targets collagen without harm to healthy or newly formed tissue
• Assists wounds in progressing from the inflammatory to proliferative phase of healing
• Helps allow granulation to proceed and epithelialization to occur


Collagenase SANTYL* Ointment is indicated for debriding chronic dermal ulcers and severely burned areas.


Collagenase SANTYL* is contraindicated in patients who have shown local or systemic hypersensitivity to collagenase.

Warnings and Precautions

The optimal pH range of Collagenase SANTYL* is 6 to 8. Higher or lower pH conditions will decrease the enzyme's activity and appropriate precautions should be taken. The enzymatic activity is also adversely affected by certain detergents and heavy metal ions, such as mercury and silver, which are used in some antiseptics. When it is suspected such materials have been used, the site should be carefully cleansed by repeated washings with normal saline before Collagenase SANTYL* Ointment is applied. Soaks containing metal ions or acidic solutions should be avoided because of the metal ion and low pH. Cleansing materials such as Dakin's solution and normal saline are compatible with Collagenase SANTYL* Ointment.

Debilitated patients should be closely monitored for systemic bacterial infections because of the theoretical possibility that debriding enzymes may increase the risk of bacteremia.

A slight transient erythema has been noted occasionally in the surrounding tissue, particularly when Collagenase SANTYL* Ointment was not confined to the wound.
Therefore, the ointment should be applied carefully within the area of the wound. Safety and effectiveness in pediatric patients have not been established.

No allergic sensitivity or toxic reactions have been noted in clinical use when used as directed. However, one case of systemic manifestations of hypersensitivity to collagenase in a patient treated for more than 1 year with a combination of collagenase and cortisone has been reported.

No systemic or local reaction attributed to overdose has been observed in clinical investigations and clinical use. If deemed necessary, the enzyme may be inactivated by washing the area with povidone iodine.

How Supplied/Sizing
Tube: 30g, 90g.
Product features
check_circle Accommodates large wounds
check_circle Accommodates small wounds
check_circle Appropriate for home use
cancel Approved for burns
check_circle Compatible w/ variety of antibiotic powders
check_circle Compatible w/ variety of cleansers
check_circle Compatible w/ variety of dressings
cancel Cream
cancel Ointment
check_circle Prepares wound bed
check_circle Solution
check_circle Tube
check_circle Unit dose
check_circle Usable on infected wounds
check_circle Variety of sizes
Other features
check_circle Educational Material Available
cancel Free Samples/Trials Available
check_circle Published Clinical Article Available
Recommended Use

Chronic Wounds
Diabetic Foot
Pressure Ulcers
Venous Ulcers

Mode of Use/Application

Collagenase SANTYL* Ointment should be applied once daily (or more frequently if the dressing becomes soiled, as from incontinence). When clinically indicated, crosshatch thick eschar with a #10 blade to allow ointment more surface contact with necrotic debris. Remove loosened detritus with forceps and scissors.

Prior to application, cleanse the wound of debris and digested material by gently rubbing with a gauze pad saturated with normal saline solution or with the desired cleansing agent compatible with Collagenase SANTYL* Ointment (See Warnings and Precautions), followed by a normal saline solution rinse.

Whenever infection is present, use an appropriate topical antibiotic powder. Apply the antibiotic to the wound prior to the application of Collagenase SANTYL* Ointment. Should the infection not respond, therapy with Collagenase SANTYL* Ointment should be discontinued until remission of the infection.

Collagenase SANTYL* Ointment may be applied directly to the wound or to a sterile gauze pad which is then applied to the wound and properly secured. Use of Collagenase SANTYL* Ointment should be discontinued when debridement of necrotic tissue is complete and granulation tissue is well established.

Removal & Change Frequency

Collagenase SANTYL* Ointment should be applied once daily (or more frequently if the dressing becomes soiled, as from incontinence).

Discontinue use of Collagenase SANTYL* Ointment when medically indicated and/or once debridement of necrotic tissue is complete and granulation tissue is well established.

Additional Recommended Dressings

Because the enzyme in Collagenase SANTYL* Ointment is activated by the hydrophilic environment of the wound, it is important to use dressings that maintain moisture balance. Avoid silver and iodine dressings; these substances inactivate collagenase.

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