Terms to Know: Complex Wound Management

DMCA.com Protection Status

Angiogenesis: The complex process in which the growth of normal, stable, and functional vessels is critically dependent on the coordinated interplay in space and time of different cell types and growth factors.1 This process involves the forming of new blood vessels from preexisting vessels by invading the wound clot to organize in a microvascular network throughout granulation tissue.

Autologous cell therapy: A therapeutic intervention that uses an individual’s cells, which are cultured and expanded outside of the body and reintroduced into the donor as a bioengineered skin substitute to aid in wound closure.

Immunomodulation: Therapeutic interventions aimed at modifying the immune response. Healing in chronic and complex wounds can be enhanced with immunomodulating agents.

How much do you know about complex wounds? Take our 10-question quiz to find out! Click here.

Intralesional injection: The direct injection of therapeutic substances, such as growth factors, into a cutaneous lesion. This method of administration delivers high concentrations of therapeutical agents while minimizing adverse side effects.

Langerhans cells: Tissue-resident dendritic cells of the skin that contain organelles called Birbeck granules. Langerhans cells are present in all layers of the epidermis but are most densely concentrated in the stratum spinosum. They are responsible for determining the immune response (inflammation) to foreign materials.

Platelet-derived growth factor: One of multiple growth factors that regulate cell growth and division. This growth factor is a potent mitogen (peptide) for cells of mesenchymal origin, such as fibroblasts, smooth muscle cells, and glial cells.

Polypeptide: A linear organic polymer with many amino acid residues bonded to form a chain of protein molecules.

Proinflammatory cytokines: Immunoregulatory cytokines that favor inflammation. The net effect of an inflammatory response is determined by the balance between proinflammatory and anti-inflammatory cytokines.

Scaffolds: Substances consisting of polymeric central components. They are used to deliver cells, drugs, and genes into the body and can aid in the closure of wounds and restoration of function.

Senescent cells: Cells that appear during late-stage healing that release a continual cascade of inflammatory cytokines, chemokines, growth factors, and proteases. The presence of these cells may prolong the inflammatory period.

Vascular endothelial growth factor (VEGF): A growth factor that aids in the growth of new blood vessels by initiating angiogenesis, proliferation, and migration of endothelial cells.

March is Complex Wound Management Month

1. Martino MM, Brkic S, Bovo E, et al. Extracellular matrix and growth factor engineering for controlled angiogenesis in regenerative medicine. Front Bioeng Biotechnol. 2015;3:45. . https://doi.org/10.3389/fbioe.2015.00045.

The views and opinions expressed in this blog are solely those of the author, and do not represent the views of WoundSource, Kestrel Health Information, Inc., its affiliates, or subsidiary companies.

Recommended for You

  • March 24th, 2021

    By Temple University School of Podiatric Medicine Journal Review Club

    The challenges of treating lower extremity wounds for podiatrists can feel more often like a marathon than a sprint. Complex and chronic wounds can add further stress on the patient and physician alike and make...

  • September 11th, 2020

    Paula Erwin-Toth, RN, MSN, FAAN

    Hello to my wound care colleagues around the world. As I write this blog, the news relating to the results of COVID-19 continues to provide evidence of the profound impact this pandemic has had on those suffering from the disease and the negative...

  • February 28th, 2022

    Wounds have a significant negative impact on patients, including pain, decreased quality of life, and social isolation. Optimal wound healing can help patients and the health care system cope with the burden of chronic wounds. Wound management may not always be the priority in patients whose...

Important Notice: The contents of the website such as text, graphics, images, and other materials contained on the website ("Content") are for informational purposes only. The Content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. The content is not intended to substitute manufacturer instructions. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition or product usage. Refer to the Legal Notice for express terms of use.