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Wound Healing in Immunocompromised Patients

Practice Accelerator
February 28, 2022


Patients who are immunocompromised present a unique and difficult challenge when considering wound care and healing. These patients may include children, older adults, organ transplant recipients, patients with cancer,1 those with diabetes mellitus, or those with HIV/AIDS.2 Immunocompromised patients are at increased risk of hypothermia,1 infection,3 and otherwise poorly healing or recurrent wounds.4 Many treatments for infection and interventions to promote wound healing rely on a properly functioning immune system.2 In immunocompromised patients, alternate treatment methods are needed to compensate for the impairments in their natural immune response.

Challenges of Wound Healing in Immunocompromised Patients

A healthy immune system consists of the innate and adaptive immune systems, each employing different cell types. The innate immune system includes neutrophils, macrophages, dendritic cells, complement proteins, and natural killer cells. The adaptive immune system includes B and T cells.2 Typical immune responses activate complex systems that can be compromised at various levels. Depending on the reason a patient is considered immunocompromised, the treatment intervention may need to be adjusted. Table 1 reviews the considerations that need to be made for wound care in various immunocompromised patient populations. However, the challenge is the same: typical wound care strategies are not necessarily effective in immunocompromised patients.

Table 1. Challenges Presented by Specific Immunocompromised Patient Populations


Specifically during the COVID-19 pandemic, immunocompromised patients have had increasingly poor wound healing outcomes. The pandemic has led to decreased access to primary and preventative care services. This change, in turn, has led to more severe infections, more hospitalizations, and more amputations, especially among diabetic patients.10 Therefore, novel approaches are needed for addressing wound care in immunocompromised patients.

Use of Advanced Technologies to Overcome Healing Obstacles

There is a growing base of novel approaches to and technologies for wound care. Choosing the right combination can help overcome the barriers to wound healing in immunocompromised patients. The following subsections describe some examples of advances in technique and technology that may positively impact wound healing in these patients.

Advanced Dressings

Advanced dressings contain a combination of materials that can target all phases of the healing process.11 In immunosuppressed patients, the wound bed may be at different phases of wound healing simultaneously as a result of microvascular issues, and the skin may be fragile. Advanced dressings can address both of these issues by impacting the wound at all levels of the healing process while also reducing the need for frequent dressing changes.


Immunosuppressants are often used with patients after skin grafting for large or deep wounds with poor closure. The literature indicates that this approach may also be used with immunosuppressed patients who have severe wounds. The immunosuppression increases the likelihood of tissue acceptance, and the skin graft can help in wound closure, reduce the risk of infection, and decrease healing time.12


Scaffolds are three-dimensional structures designed to be placed over or into a wound for support and structure. Scaffolds provide the following benefits:

  • They retain and attract cells or biomaterials needed for wound healing.
  • They facilitate cell interaction and migration.
  • They stimulate cells to elicit improved immune and wound healing response.
  • They mimic the extracellular matrix environment.

In immunocompromised patients, scaffolds can provide nutrients, cellular stimulation, and cellular migration, actions that are lacking when the immune response is suppressed or impaired.13

Stem Cell Therapy

Stem cell therapy is an emerging technology within wound care practices. It has been shown to improve both the quality and the rate of wound healing.14 However, more research is needed before stem cell therapy can be a viable option in clinical wound care patients. This therapy is currently limited to clinical trials.


Immunocompromised patients have unique wound care needs that cannot always be addressed with standard practices. These patients are at higher risk of complications and poor wound healing. Therefore, clinicians must take each patient’s particular situation into consideration and determine which advanced technologies would best overcome these obstacles. Especially during the current pandemic, patients who are immunocompromised need increased attention to prevent hospitalization, amputation, or severe infection.


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The views and opinions expressed in this blog are solely those of the author, and do not represent the views of WoundSource, HMP Global, its affiliates, or subsidiary companies.