An injury to the human body initiates a wound healing chain reaction that occurs in four sequential but overlapping phases: hemostasis, inflammatory, proliferative and maturation. This post focuses on the second (inflammatory) phase, which begins after blood flow stops (i.e., hemostasis) and...
by the WoundSource Editors
Aerobic microorganisms: Organisms thriving in an oxygen-rich environment.
Anaerobic microorganisms: Organisms thriving in an oxygen-depleted environment.
Autolytic debridement: A selective process by which endogenous phagocytic cells and proteolytic enzymes break down necrotic tissue, occurring in varying degrees in the presence of a moist wound healing environment and dependent on the patient's having a functioning immune system.
Bioburden: Normally defined as the number of bacteria living on a surface that has not been sterilized. The term is most often used in the context of bioburden testing, also known as microbial limit testing, which is a quality control test performed on medical devices and pharmaceutical products.
Biocide: An agent that kills microorganisms.
Biofilm: A complex microbial community containing self- and surface-attached microorganisms that are embedded in an extracellular polymeric substance or EPS.
Biological debridement: Application of sterile, medical-grade larvae (maggots) into the wound bed that remove any devitalized tissue, disinfect the wound bed, and thus promote wound healing. Also referred to as maggot debridement.
Clean technique: Meticulous hand washing or sanitizing that is utilized while preparing a clean field; the equipment—including gloves, instruments, and dressings—can be from multiuse or bulk packaging and not sterile for each use or application; the term non-sterile does not mean that it was not ever sterile, but that the package is multiuse and with appropriate technique can be used.
Conservative sharp debridement: Debridement performed outside the operating room; not as aggressive a procedure to make a wound acute; the removal of clearly identifiable, devitalized tissue to above the level of viable tissue by using sharp instruments, including but not limited to scalpels, scissors, or curettes.
Debridement: Removal of devitalized or necrotic material and debris from a wound.
Devitalized tissue: May include necrotic tissues, foreign debris, and bacteria, which are removed from the wound bed.
Enzymatic debridement: Debridement achieved with the use of exogenous proteolytic enzymes that work directly on the devitalized tissue or indirectly by dissolving the collagen that attaches the devitalized tissue to the wound bed and have little or no effect on healthy tissue.
Eschar: Thick, leathery, necrotic tissue located on the surface of a wound that is often tan, gray, brown, or black.
Extracellular polymeric substance (EPM): A primarily polysaccharide protective matrix synthesized and secreted by microorganisms that attaches biofilm firmly to a living or non-living surface. This protective covering does not allow the body's immune system to recognize the presence of the microorganisms; therefore, the bacteria evade an immune response, avoid detection by standard diagnostic techniques, and avoid destruction by standard treatments and therapies.
Hypochlorous acid: A naturally occurring small molecule generated by white blood cells during the oxidative burst to kill pathogens.1
Mechanical debridement: The non-selective removal or separation of necrotic tissues from the wound bed by using a using a physical method.
Microbiota and/or Microbiome: These two terms are often used to mean the same thing and are used interchangeably. The human microbiota is made up of trillions of cells, including bacteria, viruses, and fungi.
Microcolony: Mixed microbial colonies within biofilm that utilize their collective strengths and abilities to further the survival of the group; this gives significant protective advantages.
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Necrosis: (See Non-viable tissue) Tissue that is no longer viable. Can manifest as either slough or eschar.
Non-viable tissue: The general term for tissue that has died and has therefore lost its usual physical properties and biological activity. Also called devitalized tissue or necrotic tissue.
Polyhexamethylene biguanide (PHMB): A synthetic polymer that is used as a broad-spectrum preservative and antimicrobial agent in skin care.2
Serial debridement: Repeat debridement with a goal of preventing biofilm reformation.
Sharp debridement: Debridement performed in the operating room; the most efficient debridement method to convert a chronic wound to an acute wound.
Slough: A stringy or fibrinous mass that may or may not be firmly attached to surrounding tissue. Composed of serum and matrix proteins. Ranges in color from white to yellow or green (because of varying levels of bacterial colonization) to brown (hemoglobin is present). May become thicker and harder to remove the longer it is present.
Wound bed preparation: Systematic approach to wound management by identifying and removing barriers to healing including cleansing and debridement of the wound bed.
1. Liden BA. Vashe wound therapy. Podiatry Manage. 2008;Nov/Dec:121–4.
2. Hayes M. What is PHMB & is it bad? Why this skin care ingredient isn't banned in the USA. July 3, 2017. https://www.bustle.com/p/what-is-phmb-is-it-bad-why-this-skin-care-ingre.... Accessed November 25, 2018.
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